Abstract: Road transportation is the main source of air pollution in urban centers. However, air pollutant concentration relies on the transport of pollutants across scales. Brazil, the biggest country in Latin America, presents high levels of PM2.5 and ozone. Global anthropogenic emission inventories can present shortcomings due to the limited availability of local activity data and vehicle fleet-specific emission factors. In this study, we estimated road transportation emissions in Brazil between 1960 and 2100 considering different Shared Socioeconomic Pathways (SSP). We used the VEIN model with emission factors adjusted with observed local measurements made in tunnels in São Paulo. The air quality modeling was done using the Multi-Scale Infrastructure for Chemistry and Aerosols (MUSICA). This model is a configuration of the Community Atmosphere Model with chemistry (CAM-chem), a global model with a nominal resolution of 1 degree with a mesh refinement down to around 0.25 degree for the whole of South America with emissions from VEIN over Brazil and global emissions inventories elsewhere. Our results indicate the peak of CO transportation emissions occurred around the year 1980.